NFL San Francisco 49ers

San Francisco 49ers vs Cincinnati Bengals

NFL Cincinnati Bengals

Sunday December 12, 2021 at Paul Brown Stadium

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Not only did the San Francisco 49ers beat the Cincinnati Bengals in two Super Bowls, but the Bengals have also performed the worst against the Niners in the regular season as well. Since Cincinnati won their first meeting in 1974, they’re 3-11 SU – though 7-7-1 ATS..