NFL San Francisco 49ers

San Francisco 49ers vs Los Angeles Chargers

NFL Los Angeles Chargers

Sunday August 22, 2021

Bet on this game with top online sportsbooks:

50% up to $1,000 Signup Bonus

Get the latest betting odds & lines for NFL Futures at BetOnline Sportsbook for betting on your favorite sport and snag a huge sign-up bonus.

Double Your 1st Deposit Up To $1000

MyBookie is one of the best sportsbooks to bet on the NFL at all times. They have options for the preseason, future odds and money lines. Check them out for sure today!

Double Your First Deposit Up To $500 + $20 Casino Chip

Learn about the latest NFL sports betting lines, live NFL betting, and more with online sports betting at XBet.

Most believe the answer here is based in Super Bowl III, widely known as the greatest NFL upset of all-time. And with their 16-7 win SU against an 18-point spread, the New York Jets became – and have remained – the biggest underdog to win ATS in the Super Bowl.

The biggest Super Bowl favorites to date, however, were the San Francisco 49ers of Super Bowl XXIX. Going in as 19-point favorites, the 49ers made apparent that they’d be covering the 19-point spread easily, and won the game SU over the San Diego Chargers, 49-26.