Colts vs 49ers Odds and Betting Trends: October 24, 2021

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Indianapolis Colts vs San Francisco 49ers Betting News for January 2023

Colts vs 49ers Odds, Picks and Predictions

The 49ers host the Colts on Sunday Night Football. Jimmy G is expected to start after missing the last game with a calf injury. The Colts are looking for their third win in four weeks. San Francisco is coming off a bye. Indianapolis enjoyed a win last Sunday over Houston.

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